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Published on: April 6, 2017
Advances in inhalation therapy in pediatrics
Fábio Pereira Muchão1, Luiz Vicente Ribeiro Ferreira da Silva Filho
1Universidade de São Paulo (USP), São Paulo, SP, Brazil. fabiomuchao@gmail.com
Jornal De Pediatria
|October 13, 2010
Summary
For pediatric inhalation therapy, advanced inhalers improve drug delivery. Pressurized metered-dose inhalers with spacers are best for younger children, while dry powder inhalers suit older children.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Drug Delivery Systems
Background:
- Inhalation therapy is crucial for pediatric respiratory conditions.
- Conventional nebulizers present several practical challenges.
- Optimizing inhaler technique and device selection is key for effective treatment.
Purpose of the Study:
- To review technical aspects of inhalation therapy.
- To evaluate currently available inhaler devices.
- To highlight advances in pediatric inhalation therapy.
Main Methods:
- Comprehensive review of MEDLINE database articles from 1983 onwards.
- Inclusion of relevant book chapters.
- Selection of key studies based on established criteria.
Main Results:
- Breath-enhanced and breath-actuated inhalers offer advantages over conventional nebulizers.
- Dry powder inhalers with advanced dispersion mechanisms improve lung drug deposition.
- Pressurized metered-dose inhalers used with spacers significantly increase pulmonary drug deposition.
Conclusions:
- Pressurized metered-dose inhalers with spacers are recommended for children under 8 years.
- Dry powder inhalers are suitable for children over 8 years with adequate inspiratory flow.
- Device selection should consider patient age and inspiratory capacity for optimal outcomes.
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