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Published on: October 27, 2014
Recurrent astroblastoma treated with gamma knife radiosurgery
David Weintraub1, Stephen J Monteith, Chun Po Yen
1Department of Neurological Surgery, University of Virginia, PO Box 800212, Charlottesville, VA 22908, USA.
Journal of Neuro-Oncology
|October 13, 2010
Summary
Astroblastomas, rare brain tumors, can recur after surgery. Gamma Knife radiosurgery showed promise in treating a recurrent low-grade astroblastoma, reducing tumor size in a case study. This offers a potential new treatment option.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiation Oncology
Background:
- Astroblastomas are rare central nervous system tumors.
- Surgical resection is the primary treatment, but recurrences occur.
- Optimal treatment for recurrent astroblastomas remains unclear.
Observation:
- A 58-year-old woman with a recurrent low-grade astroblastoma, previously treated with multiple resections.
- The patient was referred for Gamma Knife radiosurgery due to persistent recurrence.
- Imaging identified two tumor foci in the left parietal lobe.
Findings:
- Gamma Knife radiosurgery delivered 18.00 Gy to the 50% isodose using 16 isocenters.
- Seventeen months post-treatment, follow-up imaging showed a decrease in tumor size.
- This is the first reported use of Gamma Knife radiosurgery for astroblastoma.
Implications:
- Gamma Knife radiosurgery may be a viable treatment option for recurrent astroblastomas.
- It could be particularly beneficial when complete surgical resection is not feasible.
- Further research is warranted to establish its efficacy in a larger patient cohort.
