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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 8, 2026

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

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Published on: November 1, 2014

Equine immune-mediated keratopathies.

A Matthews¹, B Gilger

¹McKenzie Bryson and Marshall, Kilmarnock, Scotland, UK.

Equine Veterinary Journal. Supplement

|October 14, 2010

Summary

Immune mediated (IMMKs) are common corneal disorders. This review details their clinical presentations and discusses current treatment challenges, highlighting the need for further research into their causes.

Area of Science:

Ophthalmology
Immunology
Corneal Diseases

Background:

Immune mediated keratopathies (IMMKs) represent a diverse group of corneal disorders.
These conditions are relatively common and present unique clinical challenges.

Purpose of the Study:

To describe the recognized clinical presentations of IMMKs in the USA and UK.
To review current understanding of IMMK aetiopathogenesis and treatment strategies.

Main Methods:

Literature review of clinical presentations and treatment outcomes for IMMKs.
Synthesis of existing knowledge on the immunological basis of corneal disorders.

Main Results:

Clinical diagnosis of IMMKs is often straightforward.

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The specific causes of IMMKs are not fully understood but involve heightened immune responses in the cornea.

Current treatments, both medical and surgical, show variable success rates.

Conclusions:

IMMKs are a significant group of corneal diseases with complex underlying mechanisms.
Treatment efficacy varies, and refractory cases or recurrences are possible.
Further research is needed to elucidate the aetiopathogenesis and improve therapeutic outcomes for IMMKs.