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Related Experiment Video

Updated: Jun 8, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Equine recurrent uveitis: the European viewpoint.

¹Veterinary Ophthalmology Service, Equine Department, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland.

Equine Veterinary Journal. Supplement

|October 14, 2010

Summary

Equine recurrent uveitis (ERU) is a significant equine disease, likely autoimmune and triggered by Leptospira spp. in Europe. Pars plana vitrectomy shows promise as a successful treatment for affected horses.

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Area of Science:

Veterinary ophthalmology
Equine medicine
Immunology

Background:

Equine recurrent uveitis (ERU) significantly impacts the European horse industry, with an 8-10% prevalence.
The exact cause of ERU is debated, but it is strongly suspected to be an autoimmune condition.
Leptospira spp. are implicated as a primary trigger for ERU in a majority of European cases.

Purpose of the Study:

To review the current understanding and therapeutic approaches for Equine Recurrent Uveitis (ERU).
To highlight the most effective treatments for ERU in the European context.

Main Methods:

Literature review of historical and current ERU management strategies.
Analysis of therapeutic outcomes, focusing on surgical interventions.

Main Results:

Therapeutic options for ERU have progressed from historical bloodletting to modern medical and surgical interventions.
Pars plana vitrectomy is identified as the most successful current therapy for ERU in horses.
Treatment efficacy is particularly noted in horses that test positive for Leptospira spp.

Conclusions:

ERU remains a critical disease in equine health, necessitating ongoing research into its autoimmune basis.
Pars plana vitrectomy represents a significant advancement in managing ERU, especially in Leptospira-positive cases.
Further understanding of ERU's etiology is crucial for developing more targeted and preventative therapies.