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Updated: Jun 8, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Estrogen therapy in menopause. Clinical study in evolution (KEEPS) to explain the risk-benefit dispute to
Arturo Zárate1, Marcelino Hernández-Valencia
1Unidad de Investigación Médica en Enfermedades Endocrinas, Diabetes y Metabolismo, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, México, DF. zaratre@att.net.mx
Abstract:
The Kronos Early Estrogen Prevention Study (KEEPS) is a randomized clinical and controlled study, with the objective of clarifying the controversy that arisen previous studies about the risk-benefit factor with use of estrogens in postmenopausal women. Healthy women aged 42-58 years who are within 36 months of their last menstrual period have been recruited to receive either oral estrogens or patches of estradiol; in addition both groups are given oral micronized progesterone for 11 days of each month. Outcomes will be carotid intimae medial thickness and the accrual of coronary calcium; collaterally subrogate outcomes will be lipoproteins concentrations, coagulation markers, bone densitometry, mammography, skin characteristics and cognitive evaluation. The hypothesis consists in the presence of a window of therapeutic opportunity for the use of estrogens in low dose in healthy women with recent menopause.
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