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Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization
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Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange

David T Lodowski1, Krzysztof Palczewski, Masaru Miyagi

  • 1Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106-4965, United States. dtl10@case.edu

Biochemistry
|October 14, 2010
PubMed

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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