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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
New family of peptidomimetics based on the imidazole motif
Sylvain Petit1, Corinne Fruit, Laurent Bischoff
1IRCOF-INSA Rouen-CNRS UMR 6014 COBRA, Université de Rouen, place Emile Blondel 76130 Mont-Saint-Aignan, France.
Organic Letters
|October 14, 2010
Abstract:
Starting from amino acid esters, new peptidomimetics based on the imidazole scaffold were prepared. An efficient and rapid sequence consisting of two subsequent one-pot procedures was developed and applied to various aminoacids. As they provide more substitution patterns, these heterocyclic mimics are promising tools for structural and biological studies.
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