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Published on: April 23, 2019
Using a portable ion mobility spectrometer to screen dietary supplements for sibutramine
Jamie D Dunn1, Connie M Gryniewicz-Ruzicka, John F Kauffman
1Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, United States. Jamie.Dunn@fda.hhs.gov
Journal of Pharmaceutical and Biomedical Analysis
|October 14, 2010
Summary
A new method detects undeclared sibutramine in supplements using portable ion mobility spectrometry in just 15 seconds. This technique offers a rapid screening tool for regulatory agencies to ensure product safety.
Area of Science:
- Analytical Chemistry
- Forensic Science
Background:
- Undeclared sibutramine in dietary supplements poses a public health risk.
- Ion mobility spectrometry (IMS) is a sensitive and rapid detection technique.
Purpose of the Study:
- To develop and evaluate a method for detecting sibutramine in dietary supplements using hand-held ion mobility spectrometers.
- To establish optimal sample preparation for accurate IMS analysis.
Main Methods:
- Analysis of supplement extracts using five portable ion mobility spectrometers.
- Determination of instrumental limit of detection and optimal concentration ranges.
- Development of a simple sample preparation procedure.
Main Results:
- The method achieved an instrumental limit of detection of 2 ng sibutramine HCl.
- Optimal sample concentrations for analysis were determined to be 2-20 ng/μl to prevent ionization chamber saturation.
- A straightforward sample preparation protocol was established.
Conclusions:
- Hand-held ion mobility spectrometry provides a rapid and sensitive method for detecting undeclared sibutramine in dietary supplements.
- The developed method and sample preparation procedure enable regulatory agencies to effectively screen products for sibutramine contamination.
