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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Novel molecular events in oral carcinogenesis via integrative approaches
1State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan, 610041, China.
Abstract:
Cancer is now viewed as a systems biology disease, and oral squamous cell carcinoma (OSCC) can be viewed in a similar fashion. In this paper, we highlight some of the novel molecular events in OSCC, revealed through an integrative strategy of systems biology based on high-throughput omics analysis such as genomics and/or proteomics, the most powerful hypothesis-generating means available today. These approaches have resulted not only in the identification of novel genes for OSCC, but also in more comprehensive networks that describe the mechanisms by which those identified events work, with the promise of developing this knowledge into biomarkers for diagnosis, prognosis, and prediction of therapeutic responses in OSCC patients. Long-term, population-based prospective studies of OSCC patients, and those at high risk of developing OSCC, will then be needed to validate these biomarkers.
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