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Related Experiment Video

Updated: Jun 8, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Autonomic imbalance in celiac children.

M Barbato¹, M Curione, S Amato

¹Department of Pediatrics, La Sapienza University, Rome, Italy.

Minerva Pediatrica

|October 14, 2010

Summary

This summary is machine-generated.

Celiac disease in children shows an enhanced sympathetic tone, even after a gluten-free diet. While gastrointestinal symptoms resolve, this autonomic imbalance persists, suggesting a complex underlying mechanism.

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Published on: December 15, 2011

Area of Science:

Pediatric Gastroenterology
Autonomic Neurology
Immunology

Background:

Celiac disease (CD) involves multiple organ systems, including the nervous system.
Autonomic neuropathy is documented in adult celiac patients, but its status in children is unexamined.
Evaluating autonomic function is crucial for a comprehensive understanding of pediatric celiac disease.

Purpose of the Study:

To investigate autonomic nervous system function in children diagnosed with celiac disease.
To assess changes in autonomic function after adherence to a gluten-free diet (GFD).

Main Methods:

Fifteen children with untreated celiac disease and fifteen healthy controls were recruited.
Autonomic function was evaluated using heart rate variability (HRV) indexes.
Serum markers, including anti-tissue transglutaminase (anti-tTG) and anti-ganglioside antibodies, were measured at baseline and after 24 months on a GFD.

Main Results:

Children with celiac disease exhibited an imbalance in the neurovegetative system, characterized by a predominant sympathetic tone.
This sympathetic predominance persisted even after 24 months of GFD.
Gastrointestinal symptoms resolved with the GFD, suggesting the sympathetic tone is not the primary cause of these symptoms.

Conclusions:

Pediatric celiac disease is associated with persistent sympathetic hyperactivity, independent of gastrointestinal symptom resolution.
The underlying cause of this sustained autonomic dysfunction in pediatric celiac disease remains undetermined.
Further research is needed to elucidate the pathogenesis of autonomic dysfunction in celiac disease.