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Genome instability as a consequence of DNA-repair and immune system abnormalities
1Tomsk Medical Institute, Department of Genetics, USSR.
Acta Biologica Hungarica
|January 1, 1990
Abstract:
The cellular level analysis of 720 clinically persons with cytogenetic abnormalities has been performed in this study. Of them 25% showed an increased number of cells with cytogenetic abnormalities. Repeated examination of these patients allowed to "eliminate" sporadic cases of genome instability from the given group. The remaining, 30% of cases, had reliable decrease in excision repair and significant changes in immunoreactivity. At the same time a decrease of activity of DNA-repair synthesis was noticed in donors with a higher number of cells with cytogenetic aberrations.