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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Push-pull nitrile ligands exhibit specific hydration patterns
Tatyana B Anisimova1, Nadezhda A Bokach, Konstantin V Luzyanin
1Department of Chemistry, St. Petersburg State University, Universitetsky Pr. 26, 198504 Stary Petergof, Russian Federation.
Dalton Transactions (Cambridge, England : 2003)
|October 14, 2010
Summary
This study details the synthesis and characterization of novel platinum(II) complexes with dialkylcyanamide ligands. Researchers explored their reactivity and structural properties, yielding bischelate and monochelate compounds with unique coordination modes.
Area of Science:
- Coordination Chemistry
- Organometallic Chemistry
- Materials Science
Background:
- Platinum complexes are vital in catalysis and medicine.
- Understanding ligand behavior in platinum coordination is crucial for developing new applications.
- Dialkylcyanamide ligands offer unique coordination possibilities.
Purpose of the Study:
- To synthesize and characterize novel platinum(II) complexes with dialkylcyanamide ligands.
- To investigate the reactivity and coordination behavior of these ligands.
- To elucidate the structures of the resulting platinum complexes.
Main Methods:
- Synthesis of cis- and trans-[PtCl(2)(NCNR(2))(Me(2)SO)] complexes.
- Reaction with excess dialkylcyanamide in water.
- Isolation and purification of cationic bischelate and monochelate complexes.
- Characterization using elemental analysis, high-resolution ESI-MS, IR, and NMR spectroscopy (1D and 2D).
- Single-crystal X-ray diffraction for structural determination.
Main Results:
- Formation of cationic bischelate [Pt{κ(2)-N,N'''-NH=C(NMe(2))OC(NMe(2))=NH}(2)](2+) (4(2+)) and monochelate complexes.
- Isolation of 4(2+) as various salts (e.g., 4·[PtCl(3)(Me(2)SO)](2)·(H(2)O)(2), 4·[pic](2), 4·[PF(6)](2), 4·[BPh(4)](2)·(NH(2)CONMe(2))).
- Observation of dialkylcyanamide ligand bond cleavage in one instance, yielding trans-[PtCl(2){N(H)C(4)H(8)O}(Me(2)SO)] (trans-7).
- Structural confirmation of key complexes via X-ray diffraction.
Conclusions:
- Novel platinum(II) complexes with dialkylcyanamide ligands have been successfully synthesized and characterized.
- The study reveals diverse coordination modes, including bischelate and monochelate structures.
- Ligand reactivity, including bond cleavage, was observed and characterized.
- Detailed structural and spectroscopic data provide insights into platinum-ligand interactions.
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