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Updated: Jun 8, 2026

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells
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Microparticles in physiological and in pathological conditions.

Maria Augusta Roos1, Luisa Gennero, Tetyana Denysenko

  • 1Department of Internal Medicine, University of Turin, Turin, Italy. gutaroos@hotmail.com

Cell Biochemistry and Function
|October 14, 2010
PubMed
Summary

Microparticles (MPs) are linked to numerous chronic diseases and organ malfunctions, impacting health systems. Research explores their role in various pathologies and potential clinical applications for improved diagnostics and treatments.

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Area of Science:

  • Biomedical Science
  • Pathology
  • Clinical Medicine

Background:

  • Chronic diseases represent a significant global health burden, exacerbated by increased lifespan without corresponding healthspan.
  • Microparticles (MPs), small cell-derived vesicles, are increasingly recognized as contributors to disease pathogenesis.

Purpose of the Study:

  • To comprehensively review the role of microparticles (MPs) in various chronic diseases.
  • To explore the diagnostic and therapeutic potential of MPs in clinical settings.

Main Methods:

  • Literature review correlating MPs with thrombotic pathologies, cardiovascular diseases, diabetes, cancer, and inflammatory conditions.
  • Exploration of MP applications in transfusion medicine, transplantation, diagnostics, and vaccination.

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Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies
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Published on: March 2, 2018

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Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells
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Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies
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Published on: March 2, 2018

Main Results:

  • MPs are implicated in diverse conditions including cardiovascular diseases, diabetes, cancer, and rheumatologic disorders.
  • Potential clinical applications include MP-based biomarkers for acute rejection, neuronal health, and disease susceptibility.

Conclusions:

  • Microparticles play a critical role in the development and progression of numerous chronic diseases.
  • Further research into MPs offers promising avenues for novel diagnostic tools and therapeutic strategies.