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Microparticles in physiological and in pathological conditions
Maria Augusta Roos1, Luisa Gennero, Tetyana Denysenko
1Department of Internal Medicine, University of Turin, Turin, Italy. gutaroos@hotmail.com
Abstract:
Chronic diseases pose a severe burden to modern National Health Systems. Individuals nowadays have a far more extended lifespan than in the past, but healthy living was only scantily extended. As much as longer life is desirable, it is saddened by chronic diseases and organ malfunctions. One contributor to these problems was recognized to be represented by microparticles (MPs). Our purpose is to better understand MPs, to contrast their ominous threat and possible clinical importance. For this intent we correlated MPs with thrombotic pathologies, hemophilia, malaria, diabetes, cardiovascular diseases, endothelial dysfunctions, pulmonary hypertension, ischemic stroke, pre-eclampsia, rheumatologic diseases-rheumatoid arthritis, polymyositis-dermatomyositis, angiogenesis and tumor progression-cancer; we listed the possibilities of using them to improve transfusion methods, as a marker for acute allograft rejection, in stem cell transplantation, as neuronal biomarkers, to understand gender-specific susceptibility for diseases and to improve vaccination methods and we presented some methods for the detection of MPs.
Insights
Microparticles (MPs) are linked to numerous chronic diseases and organ malfunctions, impacting health systems. Research explores their role in various pathologies and potential clinical applications for improved diagnostics and treatments.
Area of Science:
- Biomedical Science
- Pathology
- Clinical Medicine
Background:
- Chronic diseases represent a significant global health burden, exacerbated by increased lifespan without corresponding healthspan.
- Microparticles (MPs), small cell-derived vesicles, are increasingly recognized as contributors to disease pathogenesis.
Purpose of the Study:
- To comprehensively review the role of microparticles (MPs) in various chronic diseases.
- To explore the diagnostic and therapeutic potential of MPs in clinical settings.
Main Methods:
- Literature review correlating MPs with thrombotic pathologies, cardiovascular diseases, diabetes, cancer, and inflammatory conditions.
- Exploration of MP applications in transfusion medicine, transplantation, diagnostics, and vaccination.
Main Results:
- MPs are implicated in diverse conditions including cardiovascular diseases, diabetes, cancer, and rheumatologic disorders.
- Potential clinical applications include MP-based biomarkers for acute rejection, neuronal health, and disease susceptibility.
Conclusions:
- Microparticles play a critical role in the development and progression of numerous chronic diseases.
- Further research into MPs offers promising avenues for novel diagnostic tools and therapeutic strategies.
