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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Jun 8, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

[Multiple melanoma metastasis. Case report].

D Adam1

  • 1Universitatea de Medicină şi Farmacie Carol Davila, Bucureşti Spitalul Clinic de Urgenţă Sf.Pantelimon, Bucureşti. adam_danil@yahoo.com

Chirurgia (Bucharest, Romania : 1990)
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

Malignant melanoma can metastasize to the brain, sometimes without a detectable primary tumor. Current treatments showed limited efficacy, highlighting challenges in managing this aggressive cancer.

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Published on: March 8, 2022

Area of Science:

  • Oncology
  • Neurology
  • Dermatology

Background:

  • Malignant melanoma is a significant health concern with a high incidence.
  • Melanoma commonly metastasizes to various organs, including the brain, often presenting as encephalophilic lesions.
  • Rarely, the primary melanoma tumor remains unidentified, complicating diagnosis and treatment.

Observation:

  • A 50-year-old male presented with multiple metastases, diagnosed via MRI and PET-scan.
  • Initial treatment involved chemotherapy, radiotherapy, and immunotherapy, with subsequent development of brain metastases.
  • Despite treatment, visceral lesions progressed, and brain metastases showed no response to radiosurgery.

Findings:

  • Chemotherapy, radiotherapy, and immunotherapy failed to halt the progression of visceral melanoma metastases.
  • Surgical excision of brain metastases temporarily improved neurological status but was followed by clinical decline.
  • The patient, initially in excellent condition (KPS=100), died 3 months post-surgery. Biopsies confirmed metastatic melanoma.

Implications:

  • Metastatic melanoma without a detectable primary tumor presents a diagnostic and therapeutic challenge.
  • The limited efficacy of conventional treatments underscores the need for novel therapeutic strategies.
  • This case highlights the poor prognosis associated with advanced melanoma metastasis, particularly to the brain.