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[3,5-dimethoxyfenol--marker intoxication with Taxus baccata].

J Stríbrný¹, M Dogosi, Z Snupárek

¹UVN, U vojenské nemocnice 1200, 169 02 Praha 6. jan.stribrny@uvn.cz

Soudni Lekarstvi

|October 15, 2010

Summary

This summary is machine-generated.

Fatal yew (Taxus baccata) intoxication is difficult to diagnose. This study identifies 3,5-dimethoxyphenol in biological samples, aiding in detecting yew poisoning when plant matter is absent.

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Area of Science:

Forensic Toxicology
Analytical Chemistry
Plant Chemistry

Background:

Autopsy findings for fatal yew (Taxus baccata) intoxication are often nonspecific.
Traditional detection methods rely on identifying plant residues, which are absent when yew decoction is consumed.

Observation:

This study details the detection and quantification of 3,5-dimethoxyphenol in two fatal yew intoxication cases.
The analytical method involved liquid/liquid and solid-phase extraction, followed by methylation or acetylation and gas chromatography/mass spectrometry analysis.

Findings:

3,5-dimethoxyphenol was successfully identified and quantified in the blood of both deceased individuals, with concentrations of 82 ng/ml and 417 ng/ml.
The compound was also detected in gastric contents and urine samples from both cases, confirming its presence in biological material.

Implications:

The presence of 3,5-dimethoxyphenol serves as a reliable biomarker for yew intoxication, particularly when plant residues are not found.
This analytical approach enhances the accuracy of diagnosing fatal yew poisoning in forensic investigations.