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Achieving highly effective nonfouling performance for surface-grafted poly(HPMA) via atom-transfer radical
Chao Zhao1, Lingyan Li, Jie Zheng
1Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, United States.
Langmuir : the ACS Journal of Surfaces and Colloids
|October 15, 2010
Summary
Developing advanced antifouling surfaces for medical devices is crucial. This study optimized poly(HPMA) coatings using surface-initiated polymerization, demonstrating significant resistance to protein adsorption and cell adhesion in blood components.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Science
Background:
- Nonspecific protein adsorption on implanted devices hinders performance.
- Developing effective antifouling surfaces is critical for blood-contacting medical devices.
Purpose of the Study:
- To develop an improved method for creating antifouling surfaces using poly(HPMA) brushes.
- To evaluate protein adsorption and fibroblast adhesion on these surfaces.
Main Methods:
- Utilized a two-step method to immobilize initiator thiols on gold substrates.
- Performed surface-initiated atom-transfer radical polymerization (SI-ATRP) of hydroxypropyl methacrylate (HPMA).
- Investigated protein adsorption using surface plasmon resonance (SPR) sensors with various blood components and film thicknesses.
Main Results:
- Poly(HPMA) brushes showed high protein resistance at optimal film thicknesses (∼25-40 nm).
- Optimal thickness minimized protein adsorption from single proteins, diluted, and undiluted human plasma and serum.
- The optimized poly(HPMA) surface demonstrated resistance to fibroblast adhesion.
Conclusions:
- An improved SI-ATRP method effectively creates antifouling poly(HPMA) surfaces.
- Optimized poly(HPMA) film thickness is key to achieving excellent protein resistance.
- These antifouling poly(HPMA) materials show promise for blood-contacting medical devices.
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