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Updated: Jun 8, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Chemokine control of HIV-1 infection: beyond a binding competition
1Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA. ywu8@gmu.edu
Abstract:
A recent paper by Cameron et al. demonstrated that certain chemokines such as CCL19 activate cofilin and actin dynamics, promoting HIV nuclear localization and integration into resting CD4 T cells. Apparently, these chemokines synergize with the viral envelope protein, triggering cofilin and actin dynamics necessary for the establishment of viral latency. This study opens a new avenue for understanding chemokine interaction with HIV. Traditionally, chemokine control of HIV infection focuses on competitive binding and down-modulation of the co-receptors, particularly CCR5. This new study suggests that a diverse group of chemokines may also affect HIV infection through synergistic or antagonistic interaction with the viral coreceptor signaling pathways.
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