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Updated: Jun 8, 2026

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles
Published on: May 5, 2022
Simulations of dynamics of actin filaments by remodeling them in shear flows
Yasuhiro Inoue1, Takeji Deji, Yoshitaka Shimada
1Department of Mechanical Engineering and Science, Kyoto University, Kyoto, Japan. inoue@me.kyoto-u.ac.jp
Abstract:
A mechanochemical relationship between intracellular flow fields of actin and remodeling of actin filaments is important to the realization of cell motility. In this study, to investigate this mechanochemical relationship, we present a mathematical model describing motions of actin filament and remodeling of the filaments in shear flows. We perform simulations of the dynamics of actin filaments remodeled by polymerization, depolymerization, and severing, and investigate contributions of these remodeling processes to effective shear viscosities of the system.
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