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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Chemotherapy: which drug and when?

A Sobrero1, E Bennicelli

  • 1Department of Medical Oncology, S Martino Hospital, Genoa, Italy. alberto.sobrero@hsanmartino.it

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|October 15, 2010
PubMed
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Advanced colorectal cancer treatment is complex due to effective therapies and multiple drug options. This review focuses on chemotherapy strategies for advanced colorectal cancer, guiding treatment intensity and sequencing.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Medical Therapeutics

Background:

  • Advanced colorectal cancer treatment has evolved significantly over the past decade.
  • The increasing efficacy of therapies has transformed prognosis, making it a more indolent disease.
  • Current treatment landscape involves multiple chemotherapeutic agents, biologics, and surgical options.

Purpose of the Study:

  • To review the complexities in treating advanced colorectal cancer.
  • To focus specifically on chemotherapy strategies, excluding biologics.
  • To guide decisions on treatment intensity, initial choices, and sequential chemotherapy regimens.

Main Methods:

  • Review of current literature on advanced colorectal cancer chemotherapy.
  • Analysis of factors influencing treatment aggressiveness and choice.
  • Evaluation of chemotherapy efficacy across different lines of treatment.

Main Results:

  • Chemotherapy plays a crucial role in managing advanced colorectal cancer, improving outcomes.
  • Treatment decisions depend on factors like disease stage, patient condition, and previous therapies.
  • Optimizing the sequence of chemotherapeutic agents is key for maximizing patient benefit.

Conclusions:

  • Strategic chemotherapy selection and sequencing are vital for effective advanced colorectal cancer management.
  • The choice between aggressive treatment, watchful waiting, or single-agent chemotherapy requires careful consideration.
  • This review provides insights into optimizing chemotherapy for first, second, and subsequent lines of treatment in advanced colorectal cancer.