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Updated: Jun 8, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Multiple myeloma.

M A Dimopoulos1, E Terpos

  • 1Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece. mdimop@med.uoa.gr

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

Multiple myeloma (MM) management has advanced with novel agents, improving treatment for symptomatic patients. Treatment decisions for relapsed or refractory MM consider patient factors like age and comorbidities.

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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Published on: May 1, 2015

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Multiple myeloma (MM) is a prevalent hematological malignancy.
  • MM cell survival is influenced by interactions within the tumor microenvironment.
  • Advances in understanding MM biology have led to new therapeutic agents.

Purpose of the Study:

  • To review current treatment strategies for multiple myeloma.
  • To highlight the role of novel agents in MM management.
  • To discuss considerations for treating relapsed/refractory MM.

Main Methods:

  • Review of current literature on multiple myeloma treatment.
  • Analysis of therapeutic approaches based on patient characteristics and disease status.
  • Evaluation of novel agents and standard regimens.

Main Results:

  • Asymptomatic MM requires no immediate therapy; treatment is for symptomatic disease.
  • Induction therapy pre-autologous stem cell transplantation (ASCT) often involves bortezomib or immunomodulatory drugs (IMiDs).
  • Standard care for elderly patients includes melphalan-prednisone combinations with thalidomide (MPT) or bortezomib (MPV).

Conclusions:

  • Novel agent-based therapies are crucial for relapsed/refractory MM.
  • Treatment selection for relapsed/refractory MM must account for prior therapies, age, comorbidities, and drug safety.
  • Bortezomib-based regimens suit patients with renal impairment or bone disease, while lenalidomide-based combinations are options for those with peripheral neuropathy.
  • Post-ASCT maintenance with thalidomide may be used, but toxicity requires caution.