Searching for the molecular basis of aging: the need for life extension models

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver.

Science advances·2020

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

Nature·2016

5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.

Oncogene·2012

Genome dynamics and transcriptional deregulation in aging.

Neuroscience·2006

BRCA1 gene sequence variation in centenarians.

Annals of the New York Academy of Sciences·2002

Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.

Journal of medical genetics·2001

The pupillary light reflex in aging and Alzheimer's disease.

Aging (Milan, Italy)·2002

Summarizing amount of difficulty in ADLs: a refined characterization of disability. Results from the women's health and aging study.

Aging (Milan, Italy)·2002

A pattern of long-term predictors of health ratings among older people.

Aging (Milan, Italy)·2002

The prevalence and psychosocial characteristics of the frail elderly in Japan: a community-based study.

Aging (Milan, Italy)·2002

Homocysteine and life-style in the elderly.

Aging (Milan, Italy)·2002

In-hospital referral source and rehabilitation outcome of elderly stroke patients.

Aging (Milan, Italy)·2002

Numerical Examples of Evolutionary Processes [English Translation of "Esempi Numerici di Processi di Evoluzione" (1954)].

Artificial life·2026

How to live for centuries: common denominators of organisms with exceptional longevity.

Aging·2026

DNA methylation-based ageing in a deuterostome invertebrate: an epigenetic clock for the crown-of-thorns seastar (Acanthaster cf. solaris).

Biology letters·2026

Multi-level evidence reveals a possibly vital role of H+-pyrophosphatase in the energetic metabolism of dinoflagellate resting cysts.

Harmful algae·2026

Age-associated variation in lipid composition and nutritional quality of the invasive bivalve Anadara kagoshimensis from the Sea of Azov.

Comparative biochemistry and physiology. Part D, Genomics & proteomics·2026

Di-, tri-, and tetranucleotide frequencies covary with lifespan and genome size across protostome invertebrates.

Journal of evolutionary biology·2026

Related Experiment Videos

Searching for the molecular basis of aging: the need for life extension models

Related Concept Videos

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver.

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.

Genome dynamics and transcriptional deregulation in aging.

BRCA1 gene sequence variation in centenarians.

Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.

The pupillary light reflex in aging and Alzheimer's disease.

Summarizing amount of difficulty in ADLs: a refined characterization of disability. Results from the women's health and aging study.

A pattern of long-term predictors of health ratings among older people.

The prevalence and psychosocial characteristics of the frail elderly in Japan: a community-based study.

Homocysteine and life-style in the elderly.

In-hospital referral source and rehabilitation outcome of elderly stroke patients.

Numerical Examples of Evolutionary Processes [English Translation of "Esempi Numerici di Processi di Evoluzione" (1954)].

How to live for centuries: common denominators of organisms with exceptional longevity.

DNA methylation-based ageing in a deuterostome invertebrate: an epigenetic clock for the crown-of-thorns seastar (Acanthaster cf. solaris).

Multi-level evidence reveals a possibly vital role of H+-pyrophosphatase in the energetic metabolism of dinoflagellate resting cysts.

Age-associated variation in lipid composition and nutritional quality of the invasive bivalve Anadara kagoshimensis from the Sea of Azov.

Di-, tri-, and tetranucleotide frequencies covary with lifespan and genome size across protostome invertebrates.

Related Experiment Videos

Searching for the molecular basis of aging: the need for life extension models

Related Concept Videos

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