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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 8, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Osteosarcoma.

J Ritter1, S S Bielack

  • 1Universitätsklinikum Münster, Klinik und Poliklinik für Pädiatrische Hämatologie und Onkologie, Münster, Germany.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

Effective osteosarcoma treatment demands a multidisciplinary team and specialized centers. Therapy involves surgery and multiagent chemotherapy, including doxorubicin, methotrexate, cisplatin, and ifosfamide, to improve patient outcomes.

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Area of Science:

  • Oncology
  • Surgical Oncology
  • Pediatric Oncology

Background:

  • Osteosarcoma treatment necessitates a multidisciplinary team approach.
  • Specialized centers are crucial for comprehensive osteosarcoma care.
  • Rare malignancies like osteosarcoma benefit from multicenter trials.

Purpose of the Study:

  • To outline optimal treatment strategies for osteosarcoma.
  • To emphasize the importance of multidisciplinary care and specialized centers.
  • To highlight current challenges and future directions in osteosarcoma therapy.

Main Methods:

  • Surgical resection of all tumor sites.
  • Multiagent chemotherapy regimens including doxorubicin, high-dose methotrexate with leukovorin-rescue, cisplatin, and ifosfamide.
  • Preoperative (neoadjuvant) and postoperative (adjuvant) polychemotherapy.

Main Results:

  • Combined surgical and chemotherapeutic approaches are standard.
  • Neoadjuvant and adjuvant polychemotherapy facilitate surgical planning and prosthesis fitting.
  • Tumor response to neoadjuvant chemotherapy influences surgical strategy.

Conclusions:

  • Successful osteosarcoma treatment relies on integrated multidisciplinary care and specialized centers.
  • Standard therapy involves complete surgical removal and multiagent chemotherapy.
  • Improved strategies are needed for unresectable or relapsed osteosarcoma cases.