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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

Analytical ancestry: evolution of the array in analysis.

Larry J Kricka¹, Kenta Imai, Paolo Fortina

¹Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. kricka@mail.med.upenn.edu

Clinical Chemistry

|October 15, 2010

Summary

This summary is machine-generated.

Array-based analytical devices are crucial for high-volume parallel analysis in research and clinical labs. Their widespread acceptance is driven by automation and multiplexing capabilities, ensuring future dominance in big biology studies.

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Area of Science:

Analytical Chemistry
Biotechnology
Nanotechnology

Background:

Arrays of test sites (macro-, micro-, nanosized) are vital for high-volume parallel analysis.
This review details diverse array formats, including reaction vessels, reagents, and samples, emphasizing early variations.
Micro- and nanofabrication enhance array density and create novel analytical structures.

Purpose of the Study:

To review the diversity of array formats for analytical devices.
To highlight the historical development and applications of various array types.
To discuss the impact of micro- and nanofabrication on array technology.

Main Methods:

Literature review of early and contemporary array designs.
Categorization of array formats based on structure and application.
Discussion of fabrication technologies enabling array miniaturization and density.

Main Results:

Identified diverse array configurations: microwell strips, microplates, reagent-patterned surfaces, bead arrays, and disordered arrays for sequencing.
Demonstrated the application of micro- and nanofabrication in creating high-density DNA probe arrays and nano-scale analytical structures.
Highlighted the evolution from simple linear arrays to complex 2D and randomly ordered formats.

Conclusions:

Array-based analytical devices are integral to modern laboratories, offering high-throughput automation and multiplex analysis.
The versatility and efficiency of arrays ensure their continued importance in genomics, proteomics, and other "big biology" fields.
Ongoing advancements in fabrication technologies will further expand the capabilities and applications of array formats.