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Differential circulation of Streptococcus pneumoniae serotype 6C clones in two Israeli pediatric populations

Nurith Porat1, In Ho Park, Moon H Nahm

  • 1Pediatric Infectious Disease Unit, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel. npurat@bgu.ac.il

Journal of Clinical Microbiology
|October 15, 2010
PubMed

Insights

Streptococcus pneumoniae serotype 6C (Sp6C) was identified in Israeli children before vaccination. This Sp6C serotype was linked to Sp6A and showed distinct clonal patterns in Jewish and Bedouin populations.

Area of Science:

  • Microbiology and Immunology
  • Epidemiology
  • Genetics

Background:

  • Streptococcus pneumoniae serotype 6C (Sp6C) is a significant pathogen.
  • Understanding Sp6C epidemiology is crucial for public health interventions, especially before widespread vaccination.
  • Previous data on Sp6C prevalence and distribution in diverse populations is limited.

Purpose of the Study:

  • To genotype Streptococcus pneumoniae serotype 6C (Sp6C) isolates from distinct pediatric populations in southern Israel.
  • To determine the prevalence of Sp6C relative to other serotypes in the pre-vaccination era.
  • To analyze the clonal distribution of Sp6C and its association with serogroup 6 in Jewish and Bedouin children.

Main Methods:

  • Genotyping of Streptococcus pneumoniae isolates.
  • Serotyping to identify Sp6C and related serotypes (Sp6A).
  • Analysis of clonal clusters and population genetics.

Main Results:

  • Sp6C isolates represented 8.2% of presumed Sp6A isolates.
  • All identified Sp6C clonal clusters were associated with serogroup 6, primarily Sp6A.
  • Distinct clonal distributions of Sp6C were observed between Jewish and Bedouin subpopulations.

Conclusions:

  • Sp6C was a notable component of the Streptococcus pneumoniae serotype 6A/6C complex in southern Israel prior to vaccination.
  • The findings highlight population-specific genetic diversity within Sp6C.
  • This data provides a baseline for monitoring Sp6C dynamics post-vaccination.

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