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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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Related Experiment Video

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Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica
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Published on: August 23, 2018

Permethrin for scabies in children.

Lina Albakri1, Ran D Goldman

  • 1Pediatric Research in Emergency Therapeutics (PRETx) program (www.pretx.org) at the BC Children’s Hospital, Vancouver, BC V6H 3V4.

Canadian Family Physician Medecin De Famille Canadien
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

Topical permethrin (5% cream) is a safe and effective treatment for scabies in children over 2 months old. For infants younger than 2 months, a 7% sulfur preparation is recommended due to safety concerns with permethrin.

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Published on: March 15, 2017

Area of Science:

  • Dermatology
  • Parasitology
  • Pediatrics

Background:

  • Scabies is a common parasitic skin infection, particularly prevalent in pediatric populations.
  • Various treatment options exist for scabies, with permethrin being a frequently utilized medication.

Purpose of the Study:

  • To evaluate the safety and efficacy of permethrin as a treatment for scabies in children.
  • To determine the recommended age for permethrin use in pediatric scabies management.

Main Methods:

  • This is a review of current literature and treatment guidelines for pediatric scabies.
  • Analysis of safety and efficacy data for topical permethrin in children.

Main Results:

  • Topical permethrin 5% cream is confirmed as a safe and effective scabicide for children.
  • Permethrin is recommended as a first-line therapy for children over two months of age.

Conclusions:

  • Topical permethrin 5% cream is a safe and effective first-line treatment for pediatric scabies in patients older than 2 months.
  • For infants under 2 months, a 7% sulfur preparation is advised due to theoretical concerns about permethrin absorption.