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Published on: June 17, 2025
Bacterial culture and sensitivity in pemphigus
R B Solanki1, Y B Shah, A N Shah
1Department of Dermatology and Venereology, VS Hospital, Ellisbridge, Ahmedabad-380006, India.
Indian Journal of Dermatology, Venereology and Leprology
|October 15, 2010
Summary
Bacterial infections, particularly Staphylococcus aureus, are a leading cause of death in pemphigus vulgaris patients. This study found Staphylococcus aureus sensitive to cloxacillin, erythromycin, cefotaxime, and lincomycin, guiding antibiotic selection.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Infection is the primary cause of mortality in pemphigus vulgaris.
- Staphylococcus aureus bacteremia is the most frequent infection associated with pemphigus.
- Effective antibiotic management is crucial for improving patient outcomes.
Purpose of the Study:
- To identify common bacterial pathogens in pemphigus vulgaris lesions.
- To determine the antibiotic sensitivity patterns of isolated bacteria.
- To guide appropriate antibiotic therapy in pemphigus vulgaris patients.
Main Methods:
- Bacterial culture and sensitivity testing were performed on lesion samples from 25 pemphigus vulgaris patients.
- Antibiotics were administered based on sensitivity results alongside standard pemphigus treatment (steroids, immunosuppressants).
Main Results:
- Staphylococcus aureus was the most frequently isolated pathogenic bacterium.
- The isolated Staphylococcus aureus strains demonstrated sensitivity to cloxacillin, erythromycin, cefotaxime, and lincomycin.
Conclusions:
- Staphylococcus aureus is a prevalent pathogen in pemphigus vulgaris lesions.
- Specific antibiotics (cloxacillin, erythromycin, cefotaxime, lincomycin) are effective against common bacterial isolates in pemphigus vulgaris.
- Antimicrobial sensitivity data is essential for targeted treatment of infections in pemphigus patients.
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