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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Disorder of Water Balance01:29

Disorder of Water Balance

Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Ascites01:19

Ascites

DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...

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Related Experiment Video

Updated: Jun 8, 2026

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

Wells' syndrome.

A Chaudhary1, V Aswani, R Malkani

  • 1Department of Dermatology, Jaslok Hospital and Reserach Centre, Mumbai, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

Eosinophilic cellulitis, also known as Wells' syndrome, is a rare skin condition characterized by distinctive inflammatory plaques. Histopathology reveals abundant eosinophils and unique "flame figures" in the dermis.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Eosinophilic cellulitis, or Wells' syndrome, is an uncommon dermatosis.
  • It presents with erythematous, urticarial plaques that can become indurated and develop a grey-blue hue.

Purpose of the Study:

  • To describe the clinical and histopathological features of eosinophilic cellulitis/Wells' syndrome.
  • To highlight the characteristic diagnostic findings.

Main Methods:

  • Clinical observation of patient presentation.
  • Histopathological examination of skin biopsies.

Main Results:

  • Distinctive histopathology shows a dense dermal infiltrate rich in eosinophils.
  • Presence of 'flame figures'—collagen cores enveloped by eosinophils—is a key finding.
  • Associated findings include dermal edema and lymphocytes, histiocytes, and multinucleated histiocytes.

Conclusions:

  • Eosinophilic cellulitis/Wells' syndrome has a variable clinical course with waxing and waning.
  • The condition typically resolves spontaneously.