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Unilateral Darier's disease.

M Manimegalai1, P Kumar, S Premalatha

  • 1Department of Dermatology, Stanely Medical College, Chennai, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

Acanthosis nigricans, a skin condition causing dark, velvety patches, was diagnosed in a 60-year-old woman. Histopathology confirmed acrokeratosis verruciformis of Hopf, a rare genetic disorder affecting skin texture and appearance.

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Area of Science:

  • Dermatology
  • Medical Genetics

Background:

  • Acanthosis nigricans is a skin condition characterized by hyperpigmentation and thickening of skin folds.
  • It can be associated with various underlying conditions, including endocrine disorders and malignancies.
  • Acrokeratosis verruciformis of Hopf (AVH) is a rare genodermatosis presenting with verrucous papules and plaques.

Purpose of the Study:

  • To report a case of acanthosis nigricans with histopathological findings consistent with acrokeratosis verruciformis of Hopf.
  • To highlight the clinical presentation and diagnostic challenges of rare dermatological conditions.

Main Methods:

  • Clinical examination of a 60-year-old female patient presenting with skin lesions.
  • Histopathological analysis of a skin biopsy from a papule.

Main Results:

  • The patient presented with pruritic, crusted, greasy papules and hypopigmented macules on the forehead, retroauricular region, abdomen, mammary region, thigh, and leg.
  • Histopathology revealed features of acrokeratosis verruciformis of Hopf.

Conclusions:

  • This case underscores the importance of thorough histopathological examination for diagnosing rare skin conditions.
  • Acanthosis nigricans can sometimes present with overlapping features of other genodermatoses like AVH, necessitating careful evaluation.