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The NIH Roadmap Epigenomics Mapping Consortium

Bradley E Bernstein1, John A Stamatoyannopoulos, Joseph F Costello

  • 1Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Bernstein.Bradley@mgh.harvard.edu

Nature Biotechnology
|October 15, 2010
PubMed

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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.