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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

Updated: Jun 8, 2026

Reusable Single Cell for Iterative Epigenomic Analyses
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Published on: February 11, 2022

The NIH Roadmap Epigenomics Mapping Consortium.

Bradley E Bernstein1, John A Stamatoyannopoulos, Joseph F Costello

  • 1Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Bernstein.Bradley@mgh.harvard.edu

Nature Biotechnology
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

The NIH Roadmap Epigenomics Mapping Consortium is creating a public epigenomic map resource. This resource will detail epigenomic maps for stem cells and tissues relevant to human diseases.

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Area of Science:

  • Epigenomics
  • Genomics
  • Biomedical Research

Background:

  • The epigenome plays a crucial role in gene regulation and cellular function.
  • Understanding epigenomic alterations is vital for comprehending disease mechanisms.
  • A comprehensive resource of epigenomic data is needed for scientific advancement.

Purpose of the Study:

  • To establish a public repository of epigenomic maps.
  • To provide detailed epigenomic data for stem cells and primary tissues.
  • To create a resource representing normal tissue counterparts of disease-affected systems.

Main Methods:

  • Utilizing advanced epigenomic profiling techniques.
  • Mapping epigenetic modifications across diverse cell types.
  • Ensuring data quality and standardization for public accessibility.

Main Results:

  • Generation of a comprehensive epigenomic dataset.
  • Identification of key epigenetic patterns in stem cells and tissues.
  • Establishment of a foundational resource for epigenomic research.

Conclusions:

  • The NIH Roadmap Epigenomics Mapping Consortium is building a valuable public resource.
  • This resource will significantly advance the study of epigenetics in health and disease.
  • The generated epigenomic maps will facilitate future research and therapeutic development.