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Published on: February 19, 2019
Mononeuropathy multiplex in a patient with chronic active hepatitis B
Tai Seung Nam1, Seung Han Lee, Man Seok Park
1Department of Neurology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Journal of Clinical Neurology (Seoul, Korea)
|October 15, 2010
Summary
Chronic hepatitis B can cause immune-mediated neuropathy. This case report highlights a patient who improved with prednisone and antiviral treatment, suggesting this diagnosis for hepatitis B patients with neurological symptoms.
Area of Science:
- Neurology
- Hepatology
- Immunology
Background:
- Mononeuropathy multiplex is a rare complication of chronic hepatitis B.
- Neuropathies are more commonly reported following acute hepatitis B infections.
Purpose of the Study:
- To report a case of mononeuropathy multiplex in a patient with chronic hepatitis B.
- To highlight the potential for immune-mediated neuropathy associated with hepatitis B virus (HBV) infection.
Main Methods:
- A 30-year-old male presented with sensorimotor deficits in multiple peripheral nerves.
- Serological tests confirmed chronic active hepatitis B.
- Treatment involved oral prednisone and an antiviral agent.
Main Results:
- The patient experienced improvement in sensory and motor symptoms.
- Hepatitis B virus replication was reduced following treatment.
- This suggests an immune-mediated mechanism for the neuropathy.
Conclusions:
- Chronic immune-mediated neuropathy associated with HBV infection should be considered in the differential diagnosis of hepatitis B patients presenting with neurological symptoms.
- Early diagnosis and treatment can lead to symptom improvement and reduced viral load.
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