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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jun 8, 2026

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

Opto-electrochemical nanosensor array for remote DNA detection.

Frédérique Deiss¹, Sébastien Laurent, Emeline Descamps

¹Groupe Nanosystèmes Analytiques, Institut des Sciences Moléculaires, CNRS UMR 5255, Université Bordeaux 1, ENSCPB, 16 avenue Pey-Berland, 33607 Pessac, France.

|October 15, 2010

Summary

This summary is machine-generated.

This study presents a novel opto-electrochemical nanosensor array for remote DNA detection. The innovative design enables fluorescence imaging through an optical fiber bundle, facilitating sensitive and efficient genetic analysis.

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A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

Area of Science:

Optoelectronics
Nanotechnology
Biochemistry

Background:

Remote DNA detection is crucial for various applications, including diagnostics and environmental monitoring.
Existing methods often require complex sample preparation and specialized equipment.
There is a need for integrated, sensitive, and user-friendly DNA detection platforms.

Purpose of the Study:

To develop a high-density array of opto-electrochemical nanosensors for remote DNA detection.
To integrate electrochemical sensing with optical imaging capabilities within a single platform.
To demonstrate the feasibility of this platform for specific DNA sequence detection.

Main Methods:

Fabrication of a nanotip array by chemical etching of an optical fiber bundle.
Sputter-coating with Indium Tin Oxide (ITO) and insulation with electrophoretic paint.
Immobilization of DNA probes via electropolymerization in a polypyrrole film.
Detection of hybridized DNA using fluorescence imaging through the optical fiber bundle.

Main Results:

Successful fabrication of a high-density opto-electrochemical nanosensor array.
Retention of optical fiber bundle architecture and imaging properties.
Demonstrated DNA probe immobilization and hybridization.
Successful detection of a specific DNA sequence using fluorescence imaging and a strepavidin-R-phycoerythrin label.

Conclusions:

The developed nanostructured opto-electrochemical platform is effective for remote DNA detection.
The integrated design offers a promising approach for sensitive and efficient genetic analysis.
The platform shows potential for further development in various biosensing applications.