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Updated: Jun 8, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Central nervous system involvement in Hodgkin's lymphoma
L Galán1, A C Sánchez, B Cantos
1Department of Medical Oncology, Hospital Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain. lauragalan@telefonica.net
Abstract:
Central nervous system involvement in Hodgkin's lymphoma is extremely rare. We report three cases who had a relapse from the disease involving CNS. The most frequent causes are skull contiguity, meningeal invasion and via the hematogenous route. It is frequent that the association between Epstein-Barr Virus and Hodgkin's lymphoma, and a biopsy for confirmation, is always required. Diagnostic imaging tests like CT and MRI are useful. The standard treatment remains holocraneal radiotherapy combined with chemotherapy.
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