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Anti-listerial compounds from Asari Radix
Joonseok Oh1, In Hyun Hwang, Dong Chun Kim
1College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, 712-749, Korea.
Archives of Pharmacal Research
|October 15, 2010
Summary
Asari Radix (AR) contains compounds that inhibit Listeria monocytogenes growth. This study identifies seven compounds from AR with anti-listerial activity, marking the first report of AR
Area of Science:
- Phytochemistry
- Microbiology
- Natural Products Chemistry
Background:
- Asari Radix (AR), derived from Asarum species, is a traditional herbal medicine used for infectious diseases.
- Preliminary tests indicated that the methanol extract of AR inhibits the growth of Listeria monocytogenes.
Purpose of the Study:
- To isolate and identify compounds from Asari Radix with anti-listerial activity.
- To evaluate the efficacy of isolated compounds against Listeria monocytogenes.
Main Methods:
- Activity-guided fractionation of the methanol extract of Asari Radix.
- Isolation and structural identification of compounds using spectroscopic data.
- Antimicrobial activity testing using the agar disc diffusion method and determination of Minimum Inhibitory Concentrations (MICs).
Main Results:
- Seven compounds (1-7) were isolated and identified from the Asari Radix methanol extract.
- All seven compounds demonstrated inhibitory activity against five tested strains of Listeria monocytogenes.
- Compounds 1-3 and 7 showed potent antimicrobial effects with MICs ranging from 62.5 to 125 μg/mL.
Conclusions:
- Asari Radix contains compounds with significant inhibitory activity against Listeria monocytogenes.
- This study provides the first evidence of Asari Radix possessing anti-listerial properties.
