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Formation of Dispersible Taohong Siwu Tablets
05:44

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Published on: February 3, 2023

Improved albendazole dissolution rate in pluronic 188 solid dispersions.

Silvina G Castro1, Sergio Sanchez Bruni, Carlos E Lanusse

  • 1Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina, CONICET.

AAPS Pharmscitech
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

Solid dispersions (SDs) of albendazole (ABZ) with Pluronic 188 (P 188) enhanced drug release. Lower P 188 concentrations in SDs and physical mixtures (PMs) showed improved dissolution rates, contrary to expectations.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Low solubility drugs require strategies to enhance dissolution.
  • Solid dispersions (SDs) are a promising approach for improving drug bioavailability.
  • Albendazole (ABZ) is a low solubility antiparasitic drug.

Purpose of the Study:

  • To formulate and characterize albendazole (ABZ) solid dispersions (SDs) using Pluronic 188 (P 188).
  • To evaluate the effect of P 188 concentration on ABZ dissolution rate and physical-chemical properties.
  • To compare the performance of SDs with physical mixtures (PMs).

Main Methods:

  • Formulation of SDs and PMs with varying ABZ and P 188 concentrations.
  • Solid-state characterization using FTIR, SEM, and XRD.
  • In vitro dissolution testing.
  • Assessment of physical-mechanical properties.

Main Results:

  • No chemical interactions were observed between ABZ and P 188.
  • SDs and PMs exhibited rapid ABZ release.
  • Contrary to typical findings, lower P 188 concentrations (SD4, SD3; PM4, PM3) enhanced ABZ dissolution.
  • SDs demonstrated superior flow and compacting properties compared to PMs.

Conclusions:

  • Albendazole solid dispersions with Pluronic 188 are feasible.
  • The enhanced dissolution at lower P 188 concentrations may be linked to thermo-reversible gelation.
  • SDs offer advantages for solid dosage form manufacturing due to improved physical-mechanical properties.