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Updated: Jun 8, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
Published on: March 29, 2018
The "bone-less" bone graft: The use of bone morphogenic protein-2 in jaw reconstruction
1Department of Oral Surgery and Hospital Dentistry, Division of Oral and Maxillofacial Surgery, Indiana University School of Dentistry, Indianapolis, USA.
Abstract:
A growth factor known as Bone Morphogenic Protein has through recombinant technology been made available to dentists as a "bone-less" bone graft. This recombinant human bone morphogenic protein-2 is placed on an absorbable collagen sponge carrier and delivered to a site of bone deficiency. This material will induce new osteoblasts to form from mesenchymal stem cells in the surrounding recipient site. This eliminates the need for an autogenous bone graft and its inherent surgical morbidity. The new bone formed is of the same quality and quantity as that produced by autogenous grafting. Dentists should be familiar with alternative techniques of bone grafting in contemporary practice.
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