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Genetic restriction of protective immunity to Plasmodium yoelii sporozoites
W R Weiss1, M F Good, M R Hollingdale
1Infectious Disease Department, Naval Medical Research Institute, Bethesda, MD 20814.
Bulletin of the World Health Organization
|January 1, 1990
Abstract:
Ten congenic strains of mice were immunized with irradiated sporozoites of Plasmodium yoelii. When challenged with viable sporozoites, only two strains had a high proportion of animals which did not develop blood-stage infections. Genes both within and outside the H-2 region affected the degree of protection. Immunity did not correlate with anti-sporozoite antibody levels. In vivo depletion of CD8+ T cells did not alter immunity in two of three congenic strains, implying the existence of a novel mechanism of cell-mediated immunity.