Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anti-sporozoite antibodies.

M R Hollingdale1

  • 1Biomedical Research Institute, Rockville, MD 20852.

Bulletin of the World Health Organization
|January 1, 1990
PubMed
Summary

Developing anti-sporozoite vaccines requires understanding sporozoite-hepatic cell interactions. Further research into these interactions will refine current vaccines and guide new vaccine development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS,S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys.

Vaccine·2009
Same author

Plasmodium falciparum liver-stage antigen-1 peptide-specific interferon-gamma responses are not suppressed during uncomplicated malaria in African children.

European cytokine network·2002
Same author

Potentiation by a novel alkaloid glycoside adjuvant of a protective cytotoxic T cell immune response specific for a preerythrocytic malaria vaccine candidate antigen.

Vaccine·2001
Same author

Pre-erythrocytic immunity to Plasmodium falciparum: the case for an LSA-1 vaccine.

Trends in parasitology·2001
Same author

Influence of age and HLA type on interferon-gamma (IFN-gamma) responses to a naturally occurring polymorphic epitope of Plasmodium falciparum liver stage antigen-1 (LSA-1).

Clinical and experimental immunology·2000
Same author

Expression of TetC fusion proteins from Salmonella in a gaseous environment that models conditions found in mammalian tissues.

BioTechniques·2000

Area of Science:

  • Parasitology
  • Immunology
  • Vaccinology

Background:

  • Anti-sporozoite vaccines targeting circumsporozoite (CS) proteins are under development.
  • A comprehensive understanding of sporozoite-host cell interactions is currently lacking.

Purpose of the Study:

  • To investigate the fundamental biology of sporozoite-hepatic cell interactions.
  • To provide a scientific basis for improving existing CS protein-based vaccines.
  • To inform the design of novel vaccine candidates.

Main Methods:

  • This study focuses on the biological interactions between malaria sporozoites and liver cells.
  • Investigative approaches include cell biology and molecular analysis techniques (details not provided in abstract).

Main Results:

  • The study highlights the critical need for deeper biological insights into host-parasite interactions.
  • Understanding these mechanisms is essential for vaccine efficacy.

Conclusions:

  • Further investigation into sporozoite-hepatic cell interactions is crucial.
  • This research will enhance current vaccine strategies and enable the development of new ones.

Related Experiment Videos