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Cellular and vaccine therapeutic approaches for gliomas

Michelle J Hickey1, Colin C Malone, Kate L Erickson

  • 1The Joan S, Holmes Memorial Biotherapeutics Research Laboratory, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Journal of Translational Medicine
|October 16, 2010
PubMed

Insights

Despite advances, high-grade brain tumor prognosis remains poor. This review covers ongoing immunotherapy clinical trials, including cellular therapies and vaccines, for adult glioma patients in the US.

Area of Science:

  • Oncology
  • Immunotherapy
  • Neuro-oncology

Background:

  • High-grade primary malignant brain tumors, including gliomas, have a poor prognosis despite current standard of care therapies.
  • Experimental immunotherapy approaches, including active and passive strategies, are being investigated in early-phase clinical trials.

Purpose of the Study:

  • To provide an overview of currently open immunotherapy clinical trials for adult glioma patients in the United States.
  • To identify and discuss cellular therapies, vaccine trials, and combination immunotherapy approaches.

Main Methods:

  • A systematic search of clinicaltrials.gov was conducted.
  • The search focused on Phase I, II, and III immunotherapy trials for adult glioma patients in the US that are currently open for accrual.
  • Identified trials involving adoptive immunotherapy, cell-based and non-cell-based vaccines, and combination approaches were reviewed.

Main Results:

  • A variety of immunotherapy trials are currently open for patient accrual.
  • These include adoptive immunotherapy with ex vivo activated effector cells, various vaccine strategies (cell-based and non-cell-based), and combined passive and active immunotherapy approaches.

Conclusions:

  • Immunotherapy represents a promising area of research for high-grade gliomas.
  • Several novel immunotherapy strategies are in active clinical development, offering potential new treatment avenues for patients.

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