Related Experiment Video
Updated: Jun 8, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors
S L Deev1, M V Yasko, I L Karpenko
1Postovsky Institute of Organic Synthesis, Ekaterinburg, Russia.
Abstract:
A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from condensed 1,2,4-triazolo[5,1-c][1,2,4]triazines and 1,2,4-triazolo[1,5-a]pyrimidines, structural analogues of natural nucleic bases. Antiherpetic activity and cytotoxicity of the compounds were studied. The corresponding triphosphates of several active compounds were prepared and tested as inhibitors of DNA synthesis catalyzed by herpes simplex virus polymerase. The potential mechanism of their action is blocking of DNA dependent DNA polymerase, a key enzyme of viral replication.
Related Concept Videos
Antiviral Nucleoside Inhibitors
Herpes
Inhibitors of Viral Protein Synthesis
Genital Herpes
Inhibitors Of Virion Release
Inhibitors of Virion Maturation and Assembly

