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Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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How to Create Conditioned Taste Aversion for Grazing Ground Covers in Woody Crops with Small Ruminants
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Sheep scab control using trans-cinnamic acid.

R Wall1, P Bates

  • 1Veterinary Parasitology & Ecology Group, School of Biological Sciences, University of Bristol, BS8 1UG, UK. richard.wall@bristol.ac.uk

Veterinary Parasitology
|October 16, 2010
PubMed
Summary
This summary is machine-generated.

Trans-cinnamic acid ethyl ester shows promise for treating sheep scab mites. In vitro and in vivo studies indicate significant mite mortality, with seven of eight sheep cured, though residual activity is limited.

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Area of Science:

  • Veterinary Entomology
  • Parasitology
  • Chemical Efficacy Studies

Background:

  • Psoroptes mange mites cause sheep scab, a significant economic concern in livestock.
  • Current treatments for sheep scab can have limitations, necessitating the search for novel acaricides.

Purpose of the Study:

  • To evaluate the efficacy of trans-cinnamic acid ethyl ester against Psoroptes mange mites.
  • To determine the in vitro and in vivo effects of trans-cinnamic acid ethyl ester on sheep scab.

Main Methods:

  • In vitro assays assessed mite mortality at various concentrations and exposure times.
  • In vivo studies involved topical spray application of trans-cinnamic acid ethyl ester in a lecithin suspension on infested sheep.
  • Residual activity was tested on treated skin and cloth substrates.

Main Results:

  • In vitro, concentrations of 0.1% to 10% (v/v) resulted in 20% to 100% mite mortality within 24 hours.
  • The concentration for 95% mortality was 6.29%.
  • In vivo, 7 out of 8 sheep treated with trans-cinnamic acid ethyl ester were cured of sheep scab for 56 days, with one case of mite recovery.

Conclusions:

  • Trans-cinnamic acid ethyl ester demonstrates potent acaricidal activity against Psoroptes mites in vitro and in vivo.
  • The compound shows potential as a therapeutic agent for sheep scab, but its short residual activity may limit widespread commercial application.
  • Further development of application technology is recommended to optimize its use in managing sheep scab.