Cardiovascular co-morbidity in Asians with lupus: theoretical concern or clinical reality?

Area of Science:

• Rheumatology
• Cardiology
• Immunology

Background:

• Immuno-inflammatory diseases, such as systemic lupus erythematosus (SLE), are linked to accelerated atherosclerosis.
• Improved survival in SLE patients has led to atherosclerotic cardiovascular disease (ASCVD) becoming a major late complication.
• The prevalence and impact of ASCVD in Asian SLE patients remain under-investigated.

Purpose of the Study:

• To review the existing literature on the association between SLE and premature atherosclerosis.
• To emphasize the significance of atherosclerotic cardiovascular disease as a complication in SLE.
• To draw attention to the underrecognized burden of this comorbidity in Asian populations.

Main Methods:

• Literature review of studies examining immuno-inflammatory diseases, SLE, and atherosclerosis.
• Analysis of data focusing on cardiovascular outcomes in SLE patients.
• Synthesis of information regarding the prevalence and risk factors in diverse ethnic groups, particularly Asians.

Main Results:

• SLE is strongly associated with an increased risk of premature atherosclerosis.
• ASCVD is a significant cause of morbidity and mortality in long-term SLE survivors.
• Data on the specific burden in Asian patients is limited but suggests a potentially high prevalence.

Conclusions:

• Atherosclerotic cardiovascular disease is a critical concern for patients with systemic lupus erythematosus.
• Further research is needed to fully understand and address the burden of ASCVD in Asian SLE patients.
• Increased awareness and proactive management are crucial for mitigating cardiovascular risk in this population.