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Updated: Jun 8, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Prenatal MR imaging detection of deep medullary vein involvement in fetal brain damage
C Doneda1, A Righini, C Parazzini
1Department of Radiology and Neuroradiology, Children's Hospital V. Buzzi-ICP, Milan, Italy. chiara.doneda@icp.mi.it
Abstract:
Looking for anomalies distributed in DMV territory, we reviewed 78 fetal MR imaging examinations performed at our institution reporting unequivocal cerebral clastic lesions. We selected 3 cases, all of which had severe cardiocirculatory failure and parenchymal frontoparietal WM hemorrhagic lesions with characteristic fan-shaped distribution. Brain edema and other signs of venous hypertension were also evident. Our data suggest that in utero transient venous hypertension may be responsible for the onset of atypical frontal-located PVL.
Insights
Transient venous hypertension in utero may cause atypical periventricular leukomalacia (PVL). This study reviewed fetal MRIs, identifying 3 cases with cardiocirculatory failure and specific brain lesions.
Area of Science:
- Neurology
- Radiology
- Neonatal Medicine
Background:
- Cerebral clastic lesions in fetuses require further investigation.
- Understanding the etiology of fetal brain lesions is crucial for early intervention.
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