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Related Experiment Video

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Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity
11:41

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Published on: June 16, 2022

A WHIM-sical zebrafish.

Dennis D Hickstein1, Robert R West

  • 1National Cancer Institute, MD, USA.

Blood
|October 16, 2010
PubMed
Summary

WHIM syndrome neutrophils exhibit excessive adhesion to marrow stroma due to CXCR4 and CXCL12 interactions. A novel zebrafish embryo model visualizes these neutrophil dynamics in vivo.

Area of Science:

  • Hematology
  • Immunology
  • Developmental Biology

Background:

  • WHIM syndrome is a primary immunodeficiency characterized by neutropenia and impaired immune responses.
  • The hallmark of WHIM syndrome involves neutrophil dysfunction, specifically excessive adhesion to the bone marrow stroma.
  • This adhesion is linked to the chemokine receptor CXCR4 and its ligand CXCL12 (stromal-derived factor-1).

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