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Elevated oxidative stress markers and its relationship with endothelial dysfunction in Behçet disease
Nusret Acikgoz1, Necip Ermiş, Jülide Yağmur
1Department of Cardiology, Faculty of Medicine, Inonu University, Malatya, Turkey.
Angiology
|October 16, 2010
Summary
Oxidative stress markers like gamma-glutamyltransferase (GGT) and high-sensitivity C-reactive protein (hsCRP) are elevated in active Behçet
Area of Science:
- Immunology
- Vascular Biology
- Biochemistry
Background:
- Behçet's disease (BD) is a multisystemic inflammatory disorder.
- Endothelial dysfunction is a hallmark of BD, but its link to oxidative stress is unclear.
- Investigating oxidative stress markers in active BD is crucial for understanding disease mechanisms.
Purpose of the Study:
- To investigate the relationship between oxidative stress markers and endothelial function in patients with active Behçet's disease.
- To determine if elevated oxidative stress contributes to endothelial dysfunction in BD.
Main Methods:
- Study included 40 patients with active BD and 40 healthy controls.
- Endothelial function was assessed using flow-mediated dilatation (FMD) of the brachial artery.
- Serum levels of gamma-glutamyltransferase (GGT) and high-sensitivity C-reactive protein (hsCRP) were measured.
Main Results:
- Patients with active BD exhibited significantly lower FMD compared to controls.
- Serum GGT and hsCRP levels were significantly higher in BD patients than in controls.
- Both GGT and hsCRP levels showed an inverse correlation with FMD, indicating impaired endothelial function.
Conclusions:
- Elevated oxidative stress markers are present in patients with active Behçet's disease.
- Increased GGT and hsCRP levels are associated with endothelial dysfunction in BD.
- Oxidative stress may play a significant role in the vasculitis observed in active BD.
