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[Convulsions in neonates and early neonatal mortality]
D Branković1, R Jovanović, D Karović
1Ginekolosko-akuserska klinika, Narodni front, Beograd.
Insights
Early neonatal convulsions in infants over 2,000g birth weight are linked to high mortality, especially within the first 24 hours. Delayed onset of seizures significantly reduces neonatal mortality risk.
Area of Science:
- Neonatal Medicine
- Pediatric Neurology
- Perinatology
Context:
- Neonatal seizures represent a critical neurological emergency.
- Early-onset convulsions in newborns are associated with significant morbidity and mortality.
- This study focuses on infants with birth weight exceeding 2,000 grams.
Purpose:
- To investigate the relationship between the timing of early neonatal convulsions and mortality rates.
- To determine the mortality risk associated with early-onset seizures in a specific infant cohort.
- To analyze the impact of convulsion onset within the first 24 hours of life on neonatal survival.
Summary:
- A study of 130 infants (0.26% of births) weighing over 2,000g with early neonatal convulsions revealed a high mortality rate of 25.4%.
- Mortality peaked sharply within the first 12 hours (80.9%) and 24 hours (60.0%) after birth for neonates experiencing early convulsions.
- A statistically significant decrease in neonatal mortality was observed when convulsions occurred later (p < 0.01).
Impact:
- Highlights the critical importance of the timing of neonatal seizures in predicting outcomes.
- Underscores the need for prompt recognition and management of early-onset neonatal convulsions.
- Provides crucial data for risk stratification and clinical decision-making in neonatal care settings.
Abstract:
The relationship between the early onset of convulsions in the early neonatal period and mortality was studied in 130 (0.26%) children with the birth weight exceeding 2,000 g in whom early neonatal convulsions were recorded. Early neonatal mortality in this group was very high reaching 25.4%. The peak mortality was noted in the first 12 hrs after birth (80.9%) and in the first 24 hrs (60.0%). In the cases of a postponed occurrence of convulsions, the mortality rate of neonates significantly decreases (p less than 0.01).