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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

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Published on: July 11, 2013

Chloroquine-induced photosensitive dermatoses.

V G Prabhakara1, M Jayaraman, A Kamalam

  • 1Department of Dermatology, Madras Medical College, Madras-600003, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 16, 2010
PubMed
Summary
This summary is machine-generated.

Chloroquine, used for rheumatoid arthritis, can cause photosensitive dermatitis in patients. Symptoms improved after discontinuing the medication, highlighting a potential adverse effect of this drug.

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Area of Science:

  • Rheumatology
  • Dermatology
  • Pharmacology

Background:

  • Rheumatoid arthritis is a chronic autoimmune disease.
  • Chloroquine is a medication used to treat rheumatoid arthritis.
  • Adverse drug reactions can impact patient treatment and outcomes.

Purpose of the Study:

  • To report a case series on photosensitive dermatitis associated with chloroquine use.
  • To describe the clinical presentation and management of this adverse reaction.

Main Methods:

  • Two female patients with rheumatoid arthritis were administered chloroquine 250 mg twice daily.
  • Clinical observation for adverse effects, specifically skin reactions, was conducted.
  • The effects of chloroquine withdrawal on dermatitis were monitored.

Main Results:

  • Both patients developed photosensitive dermatitis after 4 weeks of chloroquine treatment.
  • Dermatitis symptoms gradually improved within 3-4 months following chloroquine withdrawal.

Conclusions:

  • Chloroquine may induce photosensitive dermatitis in patients with rheumatoid arthritis.
  • Discontinuation of chloroquine can lead to the resolution of drug-induced photosensitive dermatitis.
  • Clinicians should be aware of this potential side effect when prescribing chloroquine.