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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Lichen dyschromicum perstans.

A J Kanwar1, G Dawn, S Dhar

  • 1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 16, 2010
PubMed
Summary
This summary is machine-generated.

A newly identified hyperpigmentation disorder, lichen dyschromicum perstans, affects middle-aged adults, presenting as persistent, symmetrical skin lesions on the face and trunk. Histopathology shows lichenoid reactions, distinguishing it from lichen planus.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Hyperpigmentation disorders present a diagnostic challenge.
  • A common, persistent skin condition affecting middle-aged individuals was observed.
  • Lesions typically appear on the face, neck, and upper trunk.

Purpose of the Study:

  • To describe a novel disorder of hyperpigmentation.
  • To differentiate this condition from existing dermatoses.
  • To establish preliminary diagnostic criteria based on clinical and histopathological findings.

Main Methods:

  • Clinical observation of affected individuals.
  • Detailed description of lesion distribution, symmetry, and color.
  • Histopathological examination of skin biopsies.
  • Comparison with clinical features of lichen planus.

Main Results:

  • The disorder commonly affects middle-aged individuals.
  • Lesions are typically bilaterally symmetrical, affecting the face, neck, and trunk.
  • Pigmentation varies (grey to black) and persists long-term; oral mucosa is rarely involved.
  • Histopathology revealed lichenoid tissue reactions, distinct from lichen planus.

Conclusions:

  • A new disorder, tentatively named lichen dyschromicum perstans, is proposed.
  • The condition is characterized by persistent, symmetrical hyperpigmentation with lichenoid tissue reactions.
  • Further research is needed to clarify its relationship with other pigmentary disorders.