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Epistasis

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...

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Related Experiment Video

Updated: Jun 8, 2026

Methods of Pairing and Pair Maintenance of New Zealand White Rabbits (Oryctolagus Cuniculus) Via Behavioral Ethogram, Monitoring, and Interventions

Methods of Pairing and Pair Maintenance of New Zealand White Rabbits (Oryctolagus Cuniculus) Via Behavioral Ethogram, Monitoring, and Interventions

Published on: March 16, 2018

A piebald family.

L K Gupta¹, S Maru, A Mittal

¹Department of Dermato-venereo-leprology, RNT Medical College, Udipur-313001, India.

Indian Journal of Dermatology, Venereology and Leprology

|October 16, 2010

Summary

This summary is machine-generated.

Piebaldism, a rare congenital disorder causing white forelocks and skin patches, was studied in a single family across four generations. The condition affected 16 family members, illustrating its hereditary nature.

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Area of Science:

Genetics
Dermatology
Human Biology

Background:

Piebaldism is a rare congenital disorder characterized by hypopigmentation.
It presents as a white forelock and vitiligo-like amelanotic macules.
The genetic basis and inheritance patterns are of significant interest.

Purpose of the Study:

To document a family with multiple affected individuals across generations.
To illustrate the hereditary transmission of piebaldism.
To contribute to the understanding of this rare genetic condition.

Main Methods:

Family history was collected.
Clinical presentation of affected individuals was observed.
Pedigree analysis was performed.

Main Results:

Piebaldism was identified in a family spanning four successive generations.
A total of 16 family members were diagnosed with the condition.
The inheritance pattern appeared consistent with autosomal dominant transmission.

Conclusions:

Piebaldism demonstrates clear hereditary transmission within this family.
The study highlights the importance of family history in diagnosing rare genetic disorders.
Further research into the specific genetic mutations in this family may be warranted.