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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Published on: October 14, 2016

Genodermatoses in paediatric age group.

S Kumar1, R C Sharma

  • 1Department of Dermatology and STD, Lady Hardinge Medical College and Associated Hospitals, New Delhi-110001, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 16, 2010
PubMed
Summary
This summary is machine-generated.

This study analyzed genetic skin disorders in children, finding genodermatoses in 0.62% of pediatric dermatology outpatients. Ichthyosis was the most frequently observed genetic skin condition in this age group.

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Area of Science:

  • Dermatology
  • Genetics
  • Pediatrics

Background:

  • Genodermatoses are a group of inherited skin disorders.
  • Understanding their pattern in children is crucial for early diagnosis and management.
  • Pediatric dermatology services encounter various genetic skin conditions.

Purpose of the Study:

  • To investigate the pattern and relative incidence of genodermatoses in the pediatric age group.
  • To identify the most common genodermatoses presenting in a pediatric dermatology outpatient setting.

Main Methods:

  • Retrospective analysis of patient data.
  • Inclusion of cases diagnosed with genodermatoses in the pediatric age group.
  • Calculation of the relative incidence of genodermatoses.

Main Results:

  • The relative incidence of genodermatoses in the pediatric dermatology outpatient department was found to be 0.62%.
  • Ichthyosis was identified as the most common genodermatosis observed in the studied pediatric population.

Conclusions:

  • Genodermatoses represent a significant, albeit relatively uncommon, condition in pediatric dermatology.
  • Ichthyosis is a prevalent genetic skin disorder among children requiring dermatological care.
  • Further research into specific genodermatoses patterns in children is warranted.