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Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Monohybrid Crosses01:20

Monohybrid Crosses

Overview
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...

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Related Experiment Video

Updated: Jun 8, 2026

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
09:52

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

Lichen planus in monozygotic twins.

A K Mukhopadhyay1, J N Dave, S Shah

  • 1Department of Skin and STD, Bapunagar General Hospital (ESIS), Ahmedabad - 380024, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 16, 2010
PubMed
Summary

This study reports on identical twins diagnosed with lichen planus, a condition affecting both skin and nails. The case highlights the potential genetic factors in developing this inflammatory disorder.

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Published on: September 5, 2011

Related Experiment Videos

Last Updated: Jun 8, 2026

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
09:52

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Area of Science:

  • Dermatology
  • Genetics

Background:

  • Lichen planus is an inflammatory condition affecting skin, hair, nails, and mucous membranes.
  • The etiology of lichen planus is often multifactorial, involving immune, genetic, and environmental factors.

Purpose of the Study:

  • To describe a case of lichen planus in identical twins.
  • To explore the potential role of genetic predisposition in the development of lichen planus.

Main Methods:

  • Clinical presentation and diagnosis of lichen planus in both individuals.
  • Review of relevant literature on familial and genetic associations with lichen planus.

Main Results:

  • Both identical twins presented with clinically evident lichen planus affecting their skin and nails.
  • The concordance of the condition in identical twins suggests a potential genetic influence.

Conclusions:

  • The presentation of lichen planus in identical twins supports a genetic component in its pathogenesis.
  • Further research into genetic factors may elucidate the underlying mechanisms of lichen planus.